Terrestrial water availability is a key determinant of human and ecosystem well-being1,2. Apart from mean precipitation and evaporation changes3,4, it is unknown how daily-scale precipitation concentration into fewer, heavier events affects hydrologic…
Electrical signalling across distinct populations of brain cells underpins cognitive and emotional function. However, approaches that selectively regulate electrical signalling between two cellular components of a mammalian neural circuit remain sparse.…
Millions of people around the world query large language models (LLMs) for information. Although several studies have compellingly documented the persuasive potential of these models1–10, there is limited evidence of who or what influences the models…
Homo erectus remains have been found in Africa, Eurasia and Southeast Asia1–3, dating back around two million years; however, owing to their age and state of preservation, obtaining informative molecular data from them has proved challenging.…
Organ intrinsic nervous systems (OINSs) are critical components of the body–brain axis and coordinate visceral organ function with systemic physiological control1–7.…
Cellular dormancy enables survival during prolonged nutrient limitation by reversibly suppressing protein synthesis1–4. How inactive eukaryotic ribosomes are reactivated when nutrients return remains unclear.…
Optimal sleep has a vital role in promoting healthy ageing and enhancing longevity. Here we propose Sleep Chart to assess the relationship between self-reported sleep duration and 23 biological ageing clocks derived from in vivo imaging1, plasma…
The human brain relies on a complex network of connections to function, with white matter acting as the primary communication highway between different brain regions1,2.…
Bacteria encode diverse defence systems, including CRISPR–Cas, to recognize and cleave the DNA of bacteriophages (phages) and other mobile genetic elements1.…
Artificial intelligence developers are increasingly building language models with warm and friendly personas that millions of people now use for advice, therapy and companionship1.…
While human activities are driving widespread declines in wildlife populations1,2, in Central Africa, the meat of wild animals, or wild meat, represents a major component of the diets of millions of people3.…
Despite decades of biochemical and structural studies of the nucleosome1, researchers lack genome-scale methods to determine variability in nucleosome structure along individual chromatin fibres.…
The emergence of new political and social structures in Western and Central Europe during the transition from Antiquity to the Middle Ages has long been attributed to large-scale migrations.…
The US Supreme Court overturned affirmative action in 20231; however, higher-education institutions continue to make admissions decisions that affect the racial diversity of their student cohorts2–4.…
Although intrinsic metabolic pathways have critical roles in T cell function1,2, systemic nutrient availability is in constant flux. Yet, how postprandial metabolism affects T cell fate has been less studied.…
Netrin1, a developmental cue, is a master regulator of tumour epithelial-to-mesenchymal transition (EMT)1, a mechanism that is known to drive resistance to chemotherapy2.…
Human cooperation is dynamic and often declines even under favourable conditions1–4. Many prevailing theories explain the decrease of cooperation in terms of strategic behaviour or learning, framed as evidence of rational behaviour or progression towards…
