#Fig4

Electrical signalling across distinct populations of brain cells underpins cognitive and emotional function. However, approaches that selectively regulate electrical signalling between two cellular components of a mammalian neural circuit remain sparse.…

Intravenous administration of anti-CTLA4 with anti-PD1 provides durable tumour responses but causes severe treatment-related adverse events in patients with cancer1.…

An effective immune system must sample and develop healthy self-identity to prevent autoimmunity and to discern pathogenic insults1–3. Self-proteins are presented to T cells in the thymus during immune cell development2,3 and must be presented throughout…