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Protein traffic jams may explain aging, memory loss, and Alzheimer’s

Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery responsible for building proteins begins to jam and malfunction…

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Move over, AlphaFold: open-source model predicts shape of 1 billion proteins
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Move over, AlphaFold: open-source model predicts shape of 1 billion proteins

Nature·Ewen Callaway·3 days ago
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An open-source atlas generated by an AI tool called ESMFold2 vastly increases the known protein universe. An open-source atlas generated by an AI tool called ESMFold2 vastly increases the known protein universe.

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Scientists discover a weak spot shared by polio and common cold viruses
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Scientists discover a weak spot shared by polio and common cold viruses

ScienceDaily·ScienceDaily·19 days ago
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Scientists at the University of Maryland, Baltimore County, have uncovered a crucial trick used by enteroviruses—the group behind diseases like polio, myocarditis, encephalitis, and even the common cold—to reproduce inside human cells.…

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Did Homo erectus and Denisovans mate? Tooth proteins hint at ancient trysts
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Did Homo erectus and Denisovans mate? Tooth proteins hint at ancient trysts

www.nature.com·Lewis, Dyani·19 days ago
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Genetic analysis suggests interbreeding between two groups of human relatives. Genetic analysis suggests interbreeding between two groups of human relatives.

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“Simplified Proteins” Reveal the Biochemical Dawn of Early Earth
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“Simplified Proteins” Reveal the Biochemical Dawn of Early Earth

Universe Today·Andy Tomaswick·25 days ago
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When researchers look up at the sky and wonder if we’re not alone, they also realize the origins of life here on Earth might hold the key to finding out.…

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Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions
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Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions

phys.org·Carol Tseng·28 days ago
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Using bright X-rays from the Department of Energy's SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory (Berkeley Lab), researchers pioneered an innovative approach to designing proteins with targeted functions.…

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Flagella Evolution 06: Proteins as Squishy Magnetic Legos
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Flagella Evolution 06: Proteins as Squishy Magnetic Legos

Reddit r/evolution·u/C3POXTC·about 1 month ago
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I was not aware that so much of protein interactions is 'just' Brownian motion. I thought ATP is king, but it makes so much sense that those proteins just wiggle about in water until stuff happens.

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Zinc–redox crosstalk: A new key to cellular protein quality control
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Zinc–redox crosstalk: A new key to cellular protein quality control

phys.org·Kyushu University·about 1 month ago
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Zinc is an essential trace element that controls myriad biological processes. The delicate balance of its concentration in the body is critical; both deficiency and excess are linked to severe pathological states such as impaired immunity, delayed wound…

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