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Synchrotron X-rays uncover hidden protein binding sites, enabling two new functions

phys.org·Carol Tseng·28 days ago
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Starting with the designed protein apixaban-binding helical bundle (ABLE, center), researchers designed two new proteins: Kemp eliminase ABLE (KABLE, left), an enzyme with record activity, and fluorescent ABLE (FABLE, right), a compound that acts as a "light switch." Credit: Greg Stewart/SLAC National Accelerator Laboratory Using bright X-rays from the Department of Energy's SLAC National Accelerator Laboratory and Lawrence Berkeley National Laboratory (Berkeley Lab), researchers pioneered an innovative approach to designing proteins with targeted functions. Their method generated new insights that allowed the team to turn a single designed protein into two new proteins with completely different functions—one of which is the most active designed enzyme to date.…

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