Data availability The next-generation sequencing data have been deposited into the Gene Expression Omnibus under accession numbers GSE319235 (ATAC–seq), GSE319237 (bulk RNA-seq), GSE319238 (scRNA-seq), GSE319239 (CUT&Tag) and GSE319240 (HiChIP).  Source data are provided with this paper. Code availability No custom code was developed for this study. All analyses were performed using publicly available software packages as described in the Methods . References Kwakkel, G., Kollen, B. & Twisk, J. Impact of time on improvement of outcome after stroke. Stroke 37 , 2348–2353 (2006). Article   PubMed   Google Scholar   Levard, D. et al. Filling the gaps on stroke research: focus on inflammation and immunity. Brain Behav. Immun. 91 , 649–667 (2021). Article   CAS   PubMed   Google Scholar   DALYs, G. B. D. & Collaborators, H.…