It has been confirmed since February that the San Francisco 49ers will open the season in Australia against NFC West rivals the Los Angeles Rams. That is the only confirmed matchup released for San Francisco before their second international game is announced on Wednesday, with the remaining 15 games set to be revealed on Thursday, May 14. Even months after the confirmation, anticipation for the new season continues to build with each passing day. Week 1 already carries stakes unlike anything previously seen in the 49ers franchise history, and that is not an exaggeration. Why Week 1 carries extra signifcance Dec 28, 2025; Santa Clara, California, USA; San Francisco 49ers head coach Kyle Shanahan looks on in the first half against the Chicago Bears at Levi's Stadium. Mandatory Credit: Sergio Estrada-Imagn Images | Sergio Estrada-Imagn Images The 49ers and Los Angeles Rams will open their season on Thursday, September 10 at 17:35 local time, which will be 10:35 a.m. on September 11 in Australia.…