Night 1 of the NFL Draft is in the books, but the Buffalo Bills are still waiting to make their first selection after trading down three times while on the clock on Thursday. The 2025 season, which ended with a disappointment in Denver, saw the Bills desperate for help in run support, while simultaneously lacking enough depth at pass rusher to pressure opposing QBs for a full 60 minutes. With that in mind, here are four defensive linemen the Bills could target on Day 2 of the NFL Draft. Kayden McDonald β DT, Ohio State Ohio State Buckeyes defensive lineman Kayden McDonald (98) celebrates during the second half of the NCAA football game at Ohio Stadium in Columbus on Oct. 4, 2025. | Adam Cairns/Columbus Dispatch / USA TODAY NETWORK via Imagn Images Perhaps the best run stopper in the entire draft class, landing McDonald in the second round would be a perfect blend of talent, need, and positional value intertwining.β¦