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Hard-to-detect mutations explain how common autoimmune diseases arise

Nature·Sergei B. Koralov·4 days ago
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NEWS AND VIEWS 26 May 2026 An old theory gains fresh support from advanced DNA sequencing, which can detect rare mutations in B cells from people with autoimmune thyroid conditions. By Sergei B. Koralov Sergei B. Koralov is in the Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health, New York, New York 10016, USA. Timothy C. Borbet Timothy C. Borbet is in the Department of Pathology, NYU Grossman School of Medicine, NYU Langone Health, New York, New York 10016, USA. Mutations that are acquired throughout life, known as somatic mutations, are perhaps best known for their role in cancer development. Writing in Nature , Nicola et al . 1 use a high-fidelity DNA-sequencing technique to pinpoint hard-to-detect somatic mutations in immune cells, helping to clarify how some autoimmune conditions might develop.…

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