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Reading genetic activity from living cells without destroying them

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Nature Communications (2026). DOI: 10.1038/s41467-026-72072-w"> Selective NTVE reporting and cell-to-cell communication in co-cultured cells. Credit: Nature Communications (2026). DOI: 10.1038/s41467-026-72072-w Until now, studying the genetic processes in cells required destroying them—making it impossible to observe these processes over extended periods of time. A team from the Technical University of Munich (TUM) and Helmholtz Munich has developed a new method to repeatedly obtain up-to-date genetic information from living cells. In the future, this will enable better monitoring of stem cells for therapies or the effects of drugs within cells. The research is published in the journal Nature Communications . Normally, cells must be lysed for a so-called transcriptome analysis—which reveals which genes are currently being expressed—making repeated measurements on the same cells impossible.…

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