Northwestern published in Nature Nanotechnology this month. Hersam's lab printed MoS2 nanosheet memristors on flexible substrates that produced spiking waveforms within the physiologically relevant range. When tested on mouse cerebellar tissue slices, Purkinje neurons responded to the artificial spikes. The biological question I am most curious about is how meaningful the Purkinje cell response in a tissue slice actually is as a validation. Purkinje cells are some of the most elaborate neurons in the brain with those massive flat dendritic trees and very specific electrophysiology. Is triggering a response from them in a dish a reasonable proxy for what you would need to see in vivo? Or does the in vitro environment change the interpretation significantly? Also curious whether anyone has thoughts on the choice of Purkinje cells specifically.…