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A new interface to study RNA biology

phys.org·Myreille Larouche·about 1 month ago
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Genome Biology (2026). DOI: 10.1186/s13059-026-04008-y"> Structural features of target-guide interactions. Credit: Genome Biology (2026). DOI: 10.1186/s13059-026-04008-y Scientists at Université de Montréal's Institute for Research in Immunology and Cancer have developed a new database that integrates the molecular structure of microRNAs and messenger RNAs to systematically model their interactions. Called RIMap-RISC and developed by Ph.D. student Simon Chasles in the laboratory of UdeM professor François Major, director of IRIC's RNA engineering research unit, the database is detailed in a study published in Genome Biology . Various types of ribonucleic acids (RNA) are found in cells. Messenger RNA acts as an intermediary between the genetic information contained in DNA and protein synthesis. MicroRNAs are very short molecules that target messenger RNAs to degrade or inhibit them, preventing the translation of certain genes into proteins.…

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