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New imaging method maps reversed DNA replication forks in single cells

phys.org·University of Texas MD Anderson Cancer Center·30 days ago
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Nature Communications (2026). DOI: 10.1038/s41467-026-70716-5"> RF-SIRF signals are elevated under conditions promoting reversed forks. Credit: Nature Communications (2026). DOI: 10.1038/s41467-026-70716-5 Researchers at The University of Texas MD Anderson Cancer Center have developed a new imaging method, known as RF-SIRF, that quantitatively detects and maps reversed DNA replication forks with single-cell resolution. The results also demonstrated a unique epigenetic code for DNA replication stress that can be further examined to understand mechanisms of genomic stability, aging and treatment response. The study, published in Nature Communications , was led by Katharina Schlacher, Ph.D., associate professor of Cancer Biology. "By capturing reversed DNA replication forks in their spatiotemporal context, our new assay identifies site-specific epigenetic signatures," Schlacher said.…

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