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Speed 'training' prepares bacteria for complex tasks, like munching plastics

phys.org·National University of Singapore·29 days ago
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Nature Microbiology (2026). DOI: 10.1038/s41564-026-02346-y"> LySE evolves gene clusters through cycles of lysis and transduction. Credit: Nature Microbiology (2026). DOI: 10.1038/s41564-026-02346-y Millions of tons of plastic waste accumulate in landfills and oceans every year. One promising response is to engineer microbes to break the plastic down into useful chemical building blocks. However, teaching a bacterium to digest plastic efficiently demands fine-tuning not just one gene, but entire clusters of genes working in concert, like upgrading every machine on a factory assembly line rather than swapping out a single part. A new platform developed by researchers from NUS could make that possible. Called Lytic Selection and Evolution (LySE), the system harnesses a modified bacteriophage—a virus that infects bacteria—to rapidly create and test many small genetic changes.…

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