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Hidden stripe pattern lets microscopes auto-focus across 400 times deeper range

phys.org·California Institute of Technology·about 1 month ago
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Nature Communications (2026). DOI: 10.1038/s41467-026-72287-x"> Fourier spectrum of an intensity image under an oblique illumination angle. Credit: Nature Communications (2026). DOI: 10.1038/s41467-026-72287-x Anyone who has ever used a microscope knows that it takes time to bring a sample into sharp focus. Each time you move the slide, the image blurs, and you have to stop and carefully turn a knob to bring everything back into clear view. For scientists and clinicians, even if the motion is semi-automated, that time quickly adds up as they work with dozens or hundreds of samples. Now a team of scientists at Caltech has developed an inexpensive, robust fix for this problem that involves little more than a couple of LED lights and some physics-based processing. They describe the new autofocus technique, which they call Digital Defocus Aberration Interference (DAbI), in a paper published in Nature Communications .…

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