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Light-activated protein illuminates when embryos can cope with disruptions to cell division

phys.org·Hokkaido University·about 1 month ago
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Communications Biology (2026). DOI: 10.1038/s42003-026-09871-w"> Graphical abstract. Credit: Communications Biology (2026). DOI: 10.1038/s42003-026-09871-w Cell division during the early stage of embryo development is a trade-off between speed and accuracy; the cells need to divide quickly to enable rapid growth, but it's important not to introduce errors that could be fatal to the developing embryo. But some stages of embryo development might be more tolerant of errors, coping with them without leading to complete failure. To explore this, a team of researchers, led by Professor Ryota Uehara from Hokkaido University, used a light-activated chemical tool to deliberately interfere with the process of cell division at different stages of embryo development in zebrafish. The study is published in Communications Biology . This revealed that disruption was more deadly during the stage just before the embryo grows from being a single layer of cells into a more complex multilayered structure called the gastrula.…

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