New research from the University of Colorado Boulder points to a little-known brain circuit that may determine whether short-term pain fades away or becomes a long-lasting problem. The findings suggest that this pathway plays a key role in turning temporary pain into chronic pain that can persist for months or even years. The study, conducted in animals and published in the Journal of Neuroscience, focused on a region called the caudal granular insular cortex (CGIC). Researchers found that shutting down this circuit can both prevent chronic pain from developing and stop it after it has already begun. "Our paper used a variety of state-of-the art methods to define the specific brain circuit crucial for deciding for pain to become chronic and telling the spinal cord to carry out this instruction," said senior author Linda Watkins, distinguished professor of behavioral neuroscience in the College of Arts and Sciences. "If this crucial decision maker is silenced, chronic pain does not occur.…