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This organoid can menstruate — and shows how tissue can repair itself

www.nature.com·Steiner, Claudia·about 1 month ago
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Gynaecological disorders such as endometriosis could be studied using endometrium organoids. Credit: fizkes/Shutterstock Researchers have developed organoids that can regenerate like the endometrium, the lining of the uterus that sheds and re-forms during the menstrual cycle. The team used the miniature 3D structures to simulate rarely seen repair processes, which could inform future therapeutic strategies for tissue renewal and wound healing. The findings were published in Cell Stem Cell on 28 April 1 . The endometrium has a unique ability to repair itself after menstrual shedding without scarring, but how it does this is a mystery. Until this study, it had been difficult to replicate the activity in the laboratory and studying it in people is too invasive, says co-author Konstantina Nikolakopoulou, a molecular biologist who did the research while at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland.…

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