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Gene circuits reshape DNA folding and affect how genes are expressed, study finds

phys.org·Anne Trafton·about 1 month ago
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Science (2026). DOI: 10.1126/science.adw1925"> Supercoiling-mediated feedback and gene syntax couple the expression of adjacent genes. Supercoiling couples the motion of elongating RNA polymerases to the transcriptional initiation rate of adjacent genes. Influenced by this supercoiling-mediated feedback, the different gene syntaxes show distinct patterns of expression and chromatin states. Using supercoiling-informed design rules, engineered gene circuits can be optimized for robustness and performance. 3D, three dimensional. Credit: Science (2026). DOI: 10.1126/science.adw1925 When a gene is turned on in a cell, it creates a ripple effect along the DNA strand, changing the physical structure of the strand. A new study by MIT researchers, appearing in Science , shows that these ripples can stimulate or suppress neighboring genes. These effects, which result from the winding or unwinding of neighboring DNA, are determined by the order of genes along a strand of DNA.…

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