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Gene-expression patterns can be used to estimate mortality risk and chronological age

Nature·João Pedro de Magalhães·4 days ago
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NEWS AND VIEWS 27 May 2026 Massive analyses of RNA transcripts from rodents, monkeys and humans reveal hallmarks of ageing that could expedite the development of anti-ageing interventions. By João Pedro de Magalhães João Pedro de Magalhães is in the Department of Inflammation and Ageing, College of Medicine and Health, University of Birmingham, B15 2WB, UK. How quickly is a person ageing, and what is their risk of dying in the near future? Can lifespan be predicted from molecular data? These fundamental questions in ageing research have implications for drug discovery, clinical trials and precision medicine. The ability to estimate age, mortality risk and lifespan in model organisms such as rodents, is important because it can speed up the testing of interventions that aim to extend healthspan and lifespan. Writing in Nature , Tyshkovskiy et al.…

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