Oprah Winfrey is setting up shop at Amazon . The media potentate’s Harpo Entertainment has signed a comprehensive multi-year deal with the tech giant. As part of the agreement, Wondery will have exclusive distribution and advertising rights to The Oprah Podcast on audio and video. The show is also expanding to two new episodes per week starting in July. Library episodes are also included in the pact, as are franchises like “Oprah’s Book Club” and “Oprah’s Favorite Things,” which will be integrated across Amazon. As it ramps up its overall advertising efforts, with ad sales totaling $68 billion in 2025, Amazon is increasingly looking to weave its massive retail operation together with audio and video programming. Wondery, which was repositioned last year in a restructuring as a more celebrity-focused podcast outlet alongside Amazon’s Audible, is known for shows like New Heights with Jason and Travis Kelce ; Baby, This is Keke Palmer ; and Armchair Expert with Dax Shepard .…