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An experimental GLP-1 pushes the limits of weight loss. There are risks.

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Democracy Dies in Darkness

Patients lose “spectacular” amounts of weight on Eli Lilly’s GLP-1 medicine. But doctors say with greater potency comes greater risk.

May 29, 2026 at 5:00 a.m. EDTYesterday at 5:00 a.m. EDT

The headquarters of Eli Lilly in Indianapolis. (Scott Olson/Getty Images)

Eli Lilly this month unveiled startling new data that showed an experimental weight-loss drug caused people with obesity to shed, on average, 28 percent of their body weight — a substantial step up in potency from the existing crop of GLP-1 medicines.


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