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How to Accelerate Protein Structure Prediction at Proteome-Scale
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How to Accelerate Protein Structure Prediction at Proteome-Scale

NVIDIA Technical Blog·Christian Dallago·about 1 month ago
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Proteins rarely function in isolation as individual monomers. Most biological processes are governed by proteins interacting with other proteins, forming protein complexes whose structures are described in the hierarchy of protein structure as the quaternary representation.  This represents one level of complexity up from tertiary representations, the 3D structure of monomers, which are commonly known since the emergence of AlphaFold2 and the creation of the Protein Data Bank . Structural information for the vast majority of complexes remains unavailable.…

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