In his new book, The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care , Eric Topol argues that medicine is set to undergo its biggest shakeup in history, pushed by demanding consumers and the availability of game-changing technology. Topol — a cardiologist, director of the Scripps Translational Science Institute and co-founder of the West Wireless Health Institute in La Jolla, Calif. — was recently interviewed for Knowledge at Wharton by C. William Hanson, III, a professor of anesthesiology and critical care, and director, surgical intensive care, at the Hospital of the University of Pennsylvania. Hanson’s latest book is titled, Smart Medicine: How the Changing Role of Doctors Will Revolutionize Health Care, published in 2011. Below is an edited transcript of the conversation. William Hanson : I thought it might be worthwhile to quickly give you a sense of who I am and where I’m coming from [in this interview].…