First-year Buffalo Bills head coach Joe Brady will not have an easy road as he leads his team into battle for the first time in his new role. The Bills’ strength of schedule is among the most formidable in the league, with their upcoming opponents posting a win percentage of .528 a season ago, which ranks eighth for the 2026 campaign. The NFL is set to release its complete regular-season slate on Thursday night, while Buffalo’s Week 2 matchup against the Detroit Lions , in which the Bills will open the new Highmark Stadium, has already been announced. Tough matchups Buffalo Bills quarterback Josh Allen (17) runs with the ball as Houston Texans defensive end Danielle Hunter (55) applies defensive pressure during the second half at NRG Stadium. | Troy Taormina-Imagn Images Buffalo has several tough matchups on its schedule this season, including eight games against 2025 playoff teams.…