A mystery no longer. The San Francisco 49ers and their fans officially know when they will take on their opponents now that the 2026 NFL regular season schedule has been released. Some matchups will be a walk in the park for the 49ers, while others will be uphill battles . Here's what the easiest to hardest games on the 49ers' schedule are. Week 3 vs. Arizona Cardinals Sep 21, 2025; Santa Clara, California, USA; San Francisco 49ers running back Christian McCaffrey (23) carries the ball against the Arizona Cardinals during the second half at Levi's Stadium. Mandatory Credit: Cary Edmondson-Imagn Images | Cary Edmondson-Imagn Images No opponent will be easier for the 49ers to play this season than the Cardinals. They barely have any talent, no quarterback, and a first-time head coach. Oh, and this game will be the second consecutive home game after they return from Australia. Easy win.…