Most major U.S. rental car companies allow you to drive across state lines without restrictions. However, if you want to drop off your rental in a different state, you’ll typically need to book a one-way rental in advance. One-way drop-offs often come with additional fees and may have restrictions depending on the provider and location. Find a one-way rental car Quick summary . Most major U.S. rental car companies let you drive across state lines without restrictions or extra fees, as long as you return the car to your original pick-up location. Dropping off in a different state requires a one-way rental booked in advance, and you’ll likely pay additional fees for the privilege. Airports offer the most flexibility for one-way rentals compared to neighborhood locations. Driving to Canada is usually allowed , but Mexico trips are more complicated and may require extra insurance.…