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Decarboxylative alkylation of alkenes

Nature·Ritter, Tobias·about 1 month ago
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Abstract Alkenes are widely used functional groups in synthetic chemistry, important for producing polymers, detergents, agrochemicals and pharmaceuticals. When treated with electrophiles, alkenes typically undergo addition, not substitution, reactions 1 . As a consequence, the intuitive retrosynthetic disconnection to form a substituted alkene from the parent alkene does not exist in the toolbox of the chemist. For example, conversion of tri-substituted into tetra-substituted alkenes, or late-stage alkylation of complex alkenes, would provide access to molecules that are currently difficult to construct. Alkene cross-metathesis can formally alkylate appropriately substituted alkenes, but diastereoselectivity and alkene–alkyl combinations are restricted to specific cases 2 , and several classes of alkenes, such as internal or cyclic alkenes, cannot be readily alkylated with known methods 3 .…

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