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Blood-based DNA marker tracks arsenic exposure and may predict toxicity risk

phys.org·University of Chicago Medical Center·30 days ago
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Credit: CC0 Public Domain Public health experts estimate that more than 200 million people worldwide are exposed to arsenic through contaminated drinking water. Scientists know long-term exposure to arsenic is associated with increased risk of chronic illnesses like cancer and cardiovascular disease, but there hasn't been a reliable way to track these exposures and fully understand their effects on the body and the mechanisms behind them. A new study led by researchers at the University of Chicago addresses this challenge, shedding light on how arsenic leaves its mark on human DNA and offering a potential new tool for exposure assessment. In the International Journal of Epidemiology , the researchers describe a robust DNA methylation-based biomarker associated with arsenic exposure that can predict toxicity risk and serve as a model for developing other epigenetic biomarkers to help track—and potentially mitigate—the health effects of environmental toxins.…

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