Menu

📰
0

How can I reproduce NUPACK-style multi-strand nucleic acid secondary structure visualizations locally?

Reddit r/bioinformatics·u/beloved0520·about 1 month ago
#9s3HVqdG
Reading 0:00
15s threshold

How can I reproduce NUPACK-style multi-strand nucleic acid secondary structure visualizations locally? Hi everyone, I’m trying to reproduce the 2D nucleic acid secondary structure visualization style shown on the NUPACK website, but I haven’t been able to get comparable results locally. I’ve tried a few approaches, including exporting/working with local SVGs, ViennaRNA, and forna. For simple single-strand structures, the results are usually acceptable. However, as soon as I work with multi-strand complexes, the layouts become very different from the NUPACK web visualization. The differences get worse as the number of strands increases. What I’m trying to understand is: 1. What visualization/layout algorithm does NUPACK use for its 2D secondary structure diagrams? 2. Is there a local tool or library that can reproduce NUPACK-style layouts for multi-strand complexes? 3. Are there recommended workflows for exporting NUPACK structures and rendering them locally with similar geometry? 4.…

Continue reading — create a free account

Join HashtagPLUS to read full articles, follow hashtags, vote, and join the conversation.

Read More