The Architecture of Cell Fate Determination. https://aixiv.science/abs/aixiv.260526.000002 This is the culmination of 10 years of literature exploration, and about 1 year of AI use, aimed at answering a deceptively simple question, “How does life fail such that we get cancer?" Or maybe more precisely, "What are the mechanisms by which life fails that result in cancer?" My attempts at answering this question have more recently been focused on the perspective of cancer being a failed version of a developmental program that cancer cells are transitioning through. This is due to the established presence of cancer stem cells in a variety of malignancies that can reseed tumor populations, the variable differentiation states of different cancers that are associated with mortality, and some more sporadic readings.…