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CAR T-cell therapy takes woman from bedridden to 'perfectly fine'

New Scientist·#author.fullName}·about 1 month ago
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Illustration of a CAR T-cell with an implanted gene strain, resulting from the genetic modification process required for it to fight rogue cells in the body CHRISTOPH BURGSTEDT/SCIENCE PHOTO LIBRARY A woman who had three different autoimmune conditions has not required treatments for almost a year after her immune cells were genetically modified and used to kill off the rogue cells attacking her body. “She was deathly sick and bedridden at the time we met her, and we treated her, and seven days later, she got out of bed,” says Fabian Müller at the University Hospital of Erlangen in Germany. Within months she appeared to be fully recovered. “I just saw her yesterday. She’s perfectly fine,” says Müller, speaking 11 months after the treatment. This woman is one of a growing number of people with autoimmune conditions who have been successfully treated this way, and the first to have three different ones treated simultaneously.…

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