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All-in-one tool for WGS motif scanning + RNA-seq normalization + coexpression network + k-means + heatmap generation?

Reddit r/bioinformatics·u/Dismal-Surround-1449·about 1 month ago
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Does anyone know of an existing software, package, webtool, or suite that can do the full pipeline in one go?

  1. Scan whole genome sequences for user-defined motifs or motifs from public databases
  2. Integrate/enrich with expression sequencing results, including proper normalization
  3. Run k-means clustering on the combined data
  4. Generate heatmaps for visualization

  5. Generate coexpression network plots using and export in cytoscape/related software formats.

I’m looking to benchmark our in-house pipeline against established tools for QC/QA purposes.

I know TB tools-2 can do few of the tasks but still, it's not fully automated. Open to both command-line, standalone app and web-based options. Anything you’ve used and liked.

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