The day has finally arrived: the day the world sees the San Francisco 49ers ’ home and road opponents for the 2026 season. It promises to be an exciting campaign ahead, with the 49ers taking part in two international games in Australia and Mexico, facing the Los Angeles Rams and the Minnesota Vikings in Weeks 1 and 11, respectively. The NFL is tough, and the 49ers have it hard this year with those international games and a league-high travel mileage total. But here’s the stretch of the season that may ultimately prove the toughest. A tough end to the regular season Dec 22, 2025; Indianapolis, Indiana, USA; San Francisco 49ers head coach Kyle Shanahan leaves the field after the game against the Indianapolis Colts at Lucas Oil Stadium. Mandatory Credit: Trevor Ruszkowski-Imagn Images | Trevor Ruszkowski-Imagn Images After the official announcement, the 49ers will have to face the Rams (at Levi’s Stadium), the Los Angeles Chargers, the Kansas City Chiefs and the Philadelphia Eagles over a three-week period.…