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Non-chemist here is a Val-Cit + trimethyl lock linker a plausible fix for lysosomal ion trapping of basic-amine payloads?

Reddit r/Biochemistry·u/2154life·about 1 month ago
#mZfxCeOC

I work in IT, not chemistry. I've been reading papers on antibody-drug conjugates and peptide-drug conjugates for a while because I find the problem interesting, and I ended up sketching out an idea that I can't tell is obvious, already-done, or nonsense.…

15s
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Non-chemist here is a Val-Cit + trimethyl lock linker a plausible fix for lysosomal ion trapping of basic-amine payloads?

Reddit r/molecularbiology·u/2154life·about 1 month ago
#bEhX0tGa

I work in IT, not chemistry. I've been reading papers on antibody-drug conjugates and peptide-drug conjugates for a while because I find the problem interesting, and I ended up sketching out an idea that I can't tell is obvious, already-done, or nonsense.…

15s
Read More